Centellian24 PDRN Active Renew Cream – 2000 ppm PDRN Barrier Repair Cream

The iconic Madeca Cream—now enhanced with 2000 ppm PDRN.
Discover the latest evolution of the legendary Madeca Cream series.

Already sold out in Korea, this limited-edition cream was co-developed with renowned Japanese influencer Nana, inspired by her personal skincare question after professional treatments:
“How can I help the effects last longer while calming post-treatment sensitivity faster?”

After 7 months of intensive development and over 40 test samples, Centellian24 PDRN Active Renew Cream was created to help visibly restore compromised skin barriers caused by frequent professional treatments or intensive at-home active care. While focusing on calming irritation, redness, swelling, and discomfort, it also redefines the Madeca Cream signature—firmer, brighter-looking skin—with a more advanced, technology-driven identity.

Thanks to its elastic polymer structure that wraps the skin comfortably and a formula containing nine different molecular sizes of hyaluronic acid, clinical testing by the Korea Institute of Dermatological Sciences showed:

• 25.56% improvement in skin plumpness and elasticity appearance after immediate use

• 46.28% reduction in transepidermal water loss

• 9.44% visible improvement in the appearance of dark spots after one week

In addition, studies on volunteers confirmed that the cream helps reduce skin heat caused by sensitivity by up to 6.33°C after a single application, while visibly soothing puffiness and discomfort.

At the core of this advanced formula is TECA-PDRN™, a newly developed complex combining:

• TECA, Dongkook Pharmaceutical’s patented Centella Asiatica extract known for its strong soothing and antioxidant properties

• 2000 ppm PDRN

• Rose water

This powerful synergy is supported by the RE:NEW Complex, designed to help calm, hydrate, and visibly renew the skin simultaneously.

The Soothing Cooler botanical blend—made from aloe vera, seaweed, violet flower, yam, and elm root extracts—works alongside caffeine, glutathione, beta-sitosterol, and 10 types of hyaluronic acid to help reduce sensitivity while improving moisture balance and radiance.

To maximize calming and renewal benefits, this cream features an advanced 5D-PDRN Complex, derived from five sources: salmon, Centella Asiatica, heartleaf, rose, and marine-origin ingredients. This makes Active Renew PDRN the most technologically advanced member of the Madeca Cream family.

How to Use

Apply an appropriate amount as the final step of your morning or evening skincare routine.
Gently spread over the skin until fully absorbed.

Ingredients

Water, Glycerin, Dipropylene Glycol, Caprylic/Capric Triglyceride, Hydrogenated Poly(C6-14 Olefin), Glyceryl Stearate, Pentaerythrityl Tetraethylhexanoate, Niacinamide, Methoxy PEG-16 Methacrylate, Vinyl Dimethicone, Cetearyl Alcohol, Rosa Damascena Flower Water, Polyglyceryl-10 Laurate, Sodium DNA (PDRN), Madecassoside, Asiaticoside, Asiatic Acid, Centella Asiatica Extract, Glutathione, Caffeine, Beta-Sitosterol, Phytosterols, Laminaria Japonica Extract, Aloe Barbadensis Leaf Extract, Dioscorea Japonica Root Extract, Linum Usitatissimum Root Extract, Viola Mandshurica Flower Extract, Sodium Hyaluronate, Dimethylsilanol Hydroxyalginat, Hydrolyzed Hyaluronic Acid, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Sodium Hyaluronate Crosspolymer, Hydroxypropyltrimonium Hyaluronate, Sodium Acetylated Hyaluronate, 1,2-Hexanediol, Polymethylsilsesquioxane, Dicaprylyl Carbonate, Glyceryl Stearate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Butylene Glycol, Jojoba Esters, Glyceryl Stearate Citrate, Hydrogenated Polydecene, Glycosyl Trehalose, Hydrogenated Starch Hydrolysate, Behenyl Alcohol, Helianthus Annuus (Sunflower) Seed Wax, Coptis Japonica Root Extract, Ethylhexylglycerin, Lavandula Angustifolia (Lavender) Oil, Citrus Aurantium Bergamia (Bergamot) Fruit Oil, Olea Europaea (Olive) Peel Oil, Citrus Aurantium Dulcis (Orange) Peel Oil, Xanthan Gum, Rosmarinus Officinalis (Rosemary) Leaf Oil, Disodium EDTA, Adenosine, Sorbitan Isostearate, Polyacrylate-13, Anthemis Nobilis Flower Oil, Cyanocobalamin, Ascorbic Acid, Tocopheryl Acetate, Copper Tripeptide-1, Dipotassium Glycyrrhizate, Phospholipids, Hydrogenated Lecithin, Collagen Amino Acids, Hydrolyzed Elastin, Asparagine, Glutamic Acid, Glycine, Arginine, Limonene, Linalool.